[HTML][HTML] Delta/Notch-like EGF-related receptor (DNER) is not a Notch ligand
M Greene, Y Lai, K Pajcini, W Bailis, WS Pear… - PLoS …, 2016 - journals.plos.org
M Greene, Y Lai, K Pajcini, W Bailis, WS Pear, E Lancaster
PLoS One, 2016•journals.plos.orgDelta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand,
despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known
ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1
in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and
bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function
remains unknown.
despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known
ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1
in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and
bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function
remains unknown.
Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
PLOS