Susceptibility of bacterial vaginosis (BV)-associated bacteria to secnidazole compared to metronidazole, tinidazole and clindamycin
MAB Petrina, LA Cosentino, LK Rabe, SL Hillier - Anaerobe, 2017 - Elsevier
Secnidazole, a 5-nitroimidazole with a longer half-life, is structurally related to metronidazole
and tinidazole. For treatment of bacterial vaginosis (BV), secnidazole is a suitable single-
dose oral drug having a longer serum half-life than metronidazole. The objective of this
study was to evaluate the antimicrobial susceptibility of vaginal isolates of facultative and
anaerobic bacteria to secnidazole, metronidazole, tinidazole and clindamycin. A total of 605
unique BV-related bacteria and 108 isolates of lactobacilli recovered from the human vagina …
and tinidazole. For treatment of bacterial vaginosis (BV), secnidazole is a suitable single-
dose oral drug having a longer serum half-life than metronidazole. The objective of this
study was to evaluate the antimicrobial susceptibility of vaginal isolates of facultative and
anaerobic bacteria to secnidazole, metronidazole, tinidazole and clindamycin. A total of 605
unique BV-related bacteria and 108 isolates of lactobacilli recovered from the human vagina …
