Protein disulfide isomerase (PDI) is a ubiquitously expressed oxidoreductase required for
proper protein folding. It is highly concentrated in the endoplasmic reticulum, but can also be
released into the extracellular environment. Several in vivo thrombosis models have
demonstrated that vascular PDI secreted by platelets and endothelial cells is essential for
normal thrombus formation. Inhibition of extracellular PDI thus represents a potential
strategy for antithrombotic therapy. Yet this approach requires the discovery of well-tolerated …