[HTML][HTML] Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice
S Song, B Zhou, L Cheng, W Liu, Q Fan, X Ge, H Peng… - Virology Journal, 2022 - Springer
Virology Journal, 2022•Springer
The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still
poses a threat to public health worldwide. Effective next-generation vaccines and optimized
booster vaccination strategies are urgently needed. Here, we sequentially immunized mice
with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine,
and then evaluated their neutralizing antibody responses against variants including Beta,
Delta, Alpha, Iota, Kappa, and A. 23.1. These data showed that a third booster dose of …
poses a threat to public health worldwide. Effective next-generation vaccines and optimized
booster vaccination strategies are urgently needed. Here, we sequentially immunized mice
with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine,
and then evaluated their neutralizing antibody responses against variants including Beta,
Delta, Alpha, Iota, Kappa, and A. 23.1. These data showed that a third booster dose of …
Abstract
The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective next-generation vaccines and optimized booster vaccination strategies are urgently needed. Here, we sequentially immunized mice with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine, and then evaluated their neutralizing antibody responses against variants including Beta, Delta, Alpha, Iota, Kappa, and A.23.1. These data showed that a third booster dose of heterologous RBD vaccine especially after two doses of inactivated vaccines significantly enhanced the GMTs of nAbs against all SARS-CoV-2 variants we tested. In addition, the WT and variants all displayed good cross-immunogenicity and might be applied in the design of booster vaccines to induce broadly neutralizing antibodies.
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