Allergic conjunctivitis affects over 40 million patients per year in the United States. Here we
present the first murine model that incorporates the clinical, cellular, and humoral
parameters of allergic conjunctivitis, including a ragweed-induced Th2-type cytokine
production by lymphocytes. SWR/J mice were immunized with short ragweed pollen in
aluminum hydroxide. Ten days after immunization, allergic conjunctivitis was induced by
one topical application of ragweed pollen onto the eye. Immediate response was …