[HTML][HTML] Hepatocytes deficient in nuclear envelope protein lamina-associated polypeptide 1 are an ideal mammalian system to study intranuclear lipid droplets
C Östlund, A Hernandez-Ono, SJ Turk, WT Dauer… - Journal of lipid …, 2022 - ASBMB
Lipid droplets (LDs) are generally considered to be synthesized in the ER and utilized in the
cytoplasm. However, LDs have been observed inside nuclei in some cells, although recent
research on nuclear LDs has focused on cultured cell lines. To better understand nuclear
LDs that occur in vivo, here we examined LDs in primary hepatocytes from mice following
depletion of the nuclear envelope protein lamina-associated polypeptide 1 (LAP1).
Microscopic image analysis showed that LAP1-depleted hepatocytes contain frequent …
cytoplasm. However, LDs have been observed inside nuclei in some cells, although recent
research on nuclear LDs has focused on cultured cell lines. To better understand nuclear
LDs that occur in vivo, here we examined LDs in primary hepatocytes from mice following
depletion of the nuclear envelope protein lamina-associated polypeptide 1 (LAP1).
Microscopic image analysis showed that LAP1-depleted hepatocytes contain frequent …
