Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle
V Di Stefano, M Giacca, MC Capogrossi… - Journal of biological …, 2011 - ASBMB
Proliferation of mammalian cardiomyocytes stops rapidly after birth and injured hearts do not
regenerate adequately. High cyclin-dependent kinase inhibitor (CKI) levels have been
observed in cardiomyocytes, but their role in maintaining cardiomyocytes in a post-mitotic
state is still unknown. In this report, it was investigated whether CKI knockdown by RNA
interference induced cardiomyocyte proliferation. We found that triple transfection with p21
Waf1, p27 Kip1, and p57 Kip2 siRNAs induced both neonatal and adult cardiomyocyte to …
regenerate adequately. High cyclin-dependent kinase inhibitor (CKI) levels have been
observed in cardiomyocytes, but their role in maintaining cardiomyocytes in a post-mitotic
state is still unknown. In this report, it was investigated whether CKI knockdown by RNA
interference induced cardiomyocyte proliferation. We found that triple transfection with p21
Waf1, p27 Kip1, and p57 Kip2 siRNAs induced both neonatal and adult cardiomyocyte to …
