Cardiovascular Biomarker Profile on Antiretroviral Therapy Is Not Influenced by History of an IRIS Event in People With HIV and Suppressed Viremia
A Gouel-Cheron, M Nason, A Rupert… - Open Forum …, 2020 - academic.oup.com
A Gouel-Cheron, M Nason, A Rupert, V Sheikh, G Robby, GA Fahle, I Sereti
Open Forum Infectious Diseases, 2020•academic.oup.comImmune reconstitution inflammatory syndrome (IRIS) is characterized by release of
proinflammatory cytokines and tissue inflammation occurring early after antiretroviral therapy
(ART) initiation. The role of previous IRIS events in persistent chronic inflammation in people
with HIV is currently unclear. In this retrospective analysis of 143 participants who
maintained suppression of HIV viremia, we compared biomarkers related to inflammation,
coagulation, and cardiovascular risk after 3 years on ART in participants with and without a …
proinflammatory cytokines and tissue inflammation occurring early after antiretroviral therapy
(ART) initiation. The role of previous IRIS events in persistent chronic inflammation in people
with HIV is currently unclear. In this retrospective analysis of 143 participants who
maintained suppression of HIV viremia, we compared biomarkers related to inflammation,
coagulation, and cardiovascular risk after 3 years on ART in participants with and without a …
Abstract
Immune reconstitution inflammatory syndrome (IRIS) is characterized by release of proinflammatory cytokines and tissue inflammation occurring early after antiretroviral therapy (ART) initiation. The role of previous IRIS events in persistent chronic inflammation in people with HIV is currently unclear. In this retrospective analysis of 143 participants who maintained suppression of HIV viremia, we compared biomarkers related to inflammation, coagulation, and cardiovascular risk after 3 years on ART in participants with and without a history of IRIS. There was no evidence of higher levels of persistent chronic inflammation in people with HIV who had a history of an IRIS event.
ClinicalTrials.gov Identifier . NCT00286767.
Oxford University Press