Using touch-evoked response and locomotion assays to assess muscle performance and function in zebrafish
TE Sztal, AA Ruparelia, C Williams… - JoVE (Journal of …, 2016 - jove.com
Zebrafish muscle development is highly conserved with mammalian systems making them
an excellent model to study muscle function and disease. Many myopathies affecting
skeletal muscle function can be quickly and easily assessed in zebrafish over the first few
days of embryogenesis. By 24 hr post-fertilization (hpf), wildtype zebrafish spontaneously
contract their tail muscles and by 48 hpf, zebrafish exhibit controlled swimming behaviors.
Reduction in the frequency of, or other alterations in, these movements may indicate a …
an excellent model to study muscle function and disease. Many myopathies affecting
skeletal muscle function can be quickly and easily assessed in zebrafish over the first few
days of embryogenesis. By 24 hr post-fertilization (hpf), wildtype zebrafish spontaneously
contract their tail muscles and by 48 hpf, zebrafish exhibit controlled swimming behaviors.
Reduction in the frequency of, or other alterations in, these movements may indicate a …